Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and 13C-NMR Study
Abstract High-fat diet (HFD)-induced obesity is accompanied by insulin resistance and compromised Ladder brain synaptic plasticity through the impairment of insulin-sensitive pathways regulating neuronal survival, learning, and memory.Lipoic acid is known to modulate the redox status of the cell and has insulin mimetic effects.This study was aimed